There are many danger areas for health professionals in the operating room. One of the factors that affect the safety of staff are ergonomic factors. Operating room’s staff can be exposed to physical, cognitive and organizational ergonomic risk factors. Ergonomic conditions in operating rooms effects staff’s health, job satisfaction and performance. The purpose of the article is to examine the potential impact of the ergonomic factors on staff safety in the operating room in the light of the literature. In this context, the impact of ergonomic design in the operating room and the tools used on the staff safety and recommendations for the ergonomic risk factors was addressed.