Objective: The aim of this study was to investigate the relationship between handgrip strength and cough strength in healthy individuals. Methods: Demographic data were obtained from healthy university students aged 20-25 years. Dominant handgrip strength (kg) was assessed by using a hydraulic hand dynamometer (Jamar) for determining peripheral muscle strength. Cough strength was evaluated by using a portable Pef meter (L/min) by measuring the peak expiratory flow value which was occurred during a cough maneuver following a deep inspiration in sitting position. Three attempts were undertaken and the highest value was recorded for the analysis. As the data not distributed normally, the relationship between the handgrip strength and cough strength was tested by using Spearman correlation analysis and the descriptive statistics were presented median and interquartile ranges. Results: A total of 90 participants (37 female, 53 male) with a median age of 21 years and median body mass index of 22.14 kg/m2 were included in the study. The median grip strength was 46 kg and the median cough strength was 537.50 L/dk. A positive, strong, significant relationship (rho=0.750, p<0.001) was found between handgrip strength and peak expiratory flow value during cough maneuver. Conclusion: According to the results that were obtained from this study, the grip strength which is an important indicator of the peripheral muscle strength was found related to cough strength. Future studies, might investigate the utility of grip strength on cough effectiveness in healthy individuals and patients with a respiratory problem.