Aim: The aim of the research is to determine the level of innovation and entrepreneurship tendencies of the nursing students and the relationship between them. Material-Method: The universe of the cross-sectional and descriptive study consisted of 189 students enrolled in the fourth year of a nursing faculty. The sample was determined by the disproportionate cluster sampling method and all the students enrolled in the fourth class were included in the study. Data were collected using "Information Form", "Individual Innovation Scale" and "Entrepreneurship Tendency Scale". The data were analyzed using frequency-scaling, arithmetic mean, standard deviation, correlation analysis in the SPSS program. Results: The average age of the students is 21,94 ± 0,92, 81,9% is female, 52,9 % is high school graduate. Of the students, 27.7% had previously engaged in entrepreneurial activity, 90.3% did not participate in any training on entrepreneurship, 94.2% did not participate in any training on innovation, 92.3% of the respondents said that they did not take part in the health project, 30,3% followed the innovative practices in the health care system, 12,9% had their own innovative product development idea, 37,4% wanted their own innovative product development idea, 54,8% stated that innovative practices will affect nursing practices in the future. In the study it was determined that the students had low level of innovative, "interrogative" and "pioneering" features (63.12 ±7.70) and entrepreneurship over the middle (98.58±12.19). A moderately positive relationship was found between the innovation levels of the students and the entrepreneurial tendencies (r=0,41, p= 0,000). Conclusion: The results showed that nursing students had low levels of innovation, had questionable characteristics against innovations, had entrepreneurship above the middle and were open to entrepreneurship. In addition, it can be said that as the level of innovation of students increases, entrepreneurial tendencies will increase in the positive direction.