Objective: The aim of this study was to determine hopelessness levels of physiotherapy students and to examine its relation with sociodemographic.characteristics, professional awareness, occupational anxiety, professional competence and satisfaction. Methods: A total of 364 physiotherapy students studying at Istanbul University were enrolled in this study. One-hundred-fifteen of the participants were 1st grade, 95 were 2nd grade, 94 were 3rd grade and 60 were 4th grade students. Participants' sociodemographic and occupational information was questioned by the "Personal and Occupational Information Form”. The level of hopelessness was assessed using "Beck Hopelessness Scale (BHS)".Results: According BHS results, physiotherapy students were found to be in the "slight hopelessness" level. BHS was negatively correlated with gender (p=0.002, r=-0.15), and family income (p=0.86 r=-0.009). There was a significant relationship between increasing number of graduates, worries about employment, professional dignity, re-preference status and satisfaction (p<0.05). In addition, it was found that students were more likely to be anxious about getting a job (p=0.01) and felt more confident professionally in the final grade (p=0.001). Conclusion: It has been found that physiotherapy students are hopeless for the profession and it is influenced by many factors such as gender, level of family income, increasing number of graduates, worries about employment, professional dignity, dissatisfaction with the education. We think that the support of the academicians should be taken to increase the academic success of the students, professional competence and satisfaction of the department, and the number of graduation in proportion to increase in employment will increase the employment opportunities.