Infertility is a crisis situation, which causes stress and is hard to cope with. It is reported in couples that women experience more stress and they use more methods to cope with stress than men. There are also differences between the methods women and men use to cope with. In coping with infertility stress women choose to use the methods like wishing, hope and avoidance, communicating with their inner circle, attending to groups where they can share their problems, talking, searching for support, reading and attending to educations about the subject and taking responsibility. On the other hand, men prefer the coping methods like drawing their attention away from the subject, not concentrating on the situation, avoidance, controlling his feelings, concentrating on the works that he can be successful, problem solving, finding other life goals and enjoying life. In the references, different grouping studies are found in terms of coping with infertility stress. The stress experienced by the infertile couples and the methods they use to cope with should be taken into consideration while giving care. Nurses have significant roles in consulting and supporting the infertile individuals in coping with this crisis situation, which is very hard to cope with.