Aim: Health care workers are susceptible to numerous risks of danger, illness and accidents. The aim is to determine the condition of occupational health-safety and risk factors in a university hospital healthcare workers. Materials and Methods: Across-sectional study was conducted at Hatay Mustafa Kemal University Hospital in 2017. We reached 30.4% (260 healthcare worker) of there search population (855) in three days of data collection, 209 (80,0%) persons were participated. The survey and ‘‘Healthcare Worker’s Work Safety Scale’’ we reapplied. The scale is likert type, consist of 7 factors and maximum 6 points. Student-T, One Way ANOVA and Pearson Correlation tests were used. Results: The mean age of healthworkers is 30,8±6,1, 61,2% is woman, 37,8% is nurse and 24,4% is physcian. 72,7% of them are using hand sanitizer, 82,8% of them are using hand glove; 93,7% , 90,3% and 87,9% of them find soap, hand sanitizer and glov eavailable respectively. The mean score of the healthcareworkers on scale is 2,9±0,9 (1,00-5,69) and shows normal distribution (p>0,05). While woman’s mean score is 2,7±0,8, man’s is 3,2±1,0 (p=0,002). The mean score of them in medical disciplines is 2,69±0,9, surgical disciplines is 3,17±0,9 and basic sciences disciplines is 2,72±0,9 (p=0,004). They having child have high mean score (p=0,003). The lowest mean scores of the scale are on Factor-1 (occupational diseases and complaints) and Factor-4 (administrative support and approaches). Conclusion: Hospital healthworkers' job security score average is close to half of full score. Perception on occupational health and safety of woman, in medical disciplines and without having a child are lower.