Schizophrenia is a chronic disease that has destructive psychopathological effects causing profound impairments in thoughts, feelings and behaviors in individuals. Along with the physiological problems caused by disease, the patients with schizophrenia also faces prejudice, stigmatization and alienation problems caused by misinformation and beliefs in society regarding the disease. All these problems reduce the positive expectations patients with schizophrenia for the future and cause widespread despair among these patients. Hope is considered to be one of the most important determinants of healing that increases the effectiveness of the treatment, enabling patients with schizophrenia to fight against the disease. Nurses are the most prominent health care professionals, which are close the patients in the diagnosis, treatment, and rehabilitation stages of the schizophrenia disease. Therefore, interventions used for increasing hope should be known by nurses well. The aim of this review is to guide nurses to perform interventions to determine and increase the levels of hope of the patients with schizophrenia as well as raising awareness in this regard.